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Dmg page 843/6/2023 ![]() A better understanding of the cellular events involved in the pathogenesis and progression of CLL should lead to more specific and less toxic therapies, with early treatment in patients at risk, and possibly enabling cure.Īdaptive and innate immune responses are orchestrated by the dynamic interactions between cell-surface molecules. Despite major progress in the last few years in the understanding of the biology and pathophysiology of this disease, as well as the development of better treatment modalities, CLL remains incurable in most patients and even control of the disease requires aggressive treatment with significant side effects. The main feature of the disease is decreased apoptosis, resulting in the pathologic accumulation of these malignant cells 1. Chronic lymphocytic leukemia is the most common leukemia in the Western world and is characterized by the progressive accumulation of small mature CD5 + lymphocytes, in the peripheral blood, lymphoid organs and bone marrow (BM).
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